USC ENDOCRINE LABORATORIES

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TEST INDEX


Thyroglobulin (Tg) Tg Antibody TSH Free T4 Total T4 Free T3 Total T3 TPO Antibody
THBR FT4I or FT3I TBG Calcitonin PTH


CALCITONIN (CTN)

Methodology  Chemiluminescence Immunoassay

Performed  Mon - Fri

Reported  Mon – Fri

Collect  Serum:  One 6 mL RT (Min: 4 mL RT)     FNAW:  1.0 mL in saline

Transport  Serum:  2.0 mL frozen serum (Min: 0.5 mL)     FNAW: 1.0 mL frozen washout in saline

Stability  Stable for 15 days if frozen at -20°C.  Longer at -70°C.
           
Unacceptable  Slightly and moderately lipemic, hemolyzed or icteric samples are acceptable.  Samples that are grossly lipemic, icteric or hemolyzed are to be brought to the attention of the technical supervisor for approval.  Do not use EDTA plasma.

Reference Range  Serum:  <2.0-8.4 pg/mL for male, <2.0-5.0 pg/mL for female   FNAW:  <2.0 pg/mL

CPT Code  82308

Information:  The physiological significance of calcitonin is uncertain, but it does have a modest calcium- and phosphorus-lowering effect.  Its secretion is normally modulated by rising and falling calcium levels, with an increase in circulating calcium prompting an increase in the calcitonin level.  Elevated concentrations of calcitonin are predominantly encountered in patients with medullary thyroid carcinoma, leukemia, myeloproliferative disorders, hyperparathyroidism, hypergastrinemia, rental failure and chronic inflammatory disease.  It may be produced ectopically by lung or breast tumors also but its measurement is not used in the diagnosis of such disorders.

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