USC
ENDOCRINE LABORATORIES
TEST INDEX
ANTI-THYROGLOBULIN ANTIBODY (TgAb)
Methodology
Radioimmunoassay
Performed
Mon – Fri
Reported
Next Working Day
Collect
One 6
mL RT (Min: 4 mL RT)
Transport
2.0 mL
refrigerated
serum (Min: 0.8 mL)
Stability
Stored at
2 - 8°C until
used; Stable if frozen at - 20°C
Unacceptable:
Whole
blood/Plasma; Slightly and
moderately lipemic, hemolyzed or icteric samples are
acceptable. Samples that are grossly lipemic, icteric or
hemolyzed are to be brought to the attention of the technical
supervisor for approval.
Reference
Range <0.4
U/mL
CPT
Code 86800
Information: This
highly
sensitive, direct radioimmunoassay
system is based on the use of a highly purified, stable preparation of
125I labeled Thyroglobulin. The assay is standardized against
the
MRC Thyroglobulin Auto-antibody First International Reference
Preparation (Coded 65/93).
Measurement of thyroglobulin auto-antibodies can be of considerable
value in the diagnosis of thyroid diseases, such as autoimmune
thyroiditis, Graves' disease, endemic goiter and subacute
thyroiditis. These measurements when used as part of a
thyroid
autoimmune diagnostic profile, which would include Anti Thyroid
Peroxidase Antibody and Thyrotropin Receptor antibody, can be very
useful in the differential diagnosis and management of thyroid
disease. TgAb is always to be run in conjunction with
Thyroglobulin (Tg) sera in order to conform to NACB guidelines (Thyroid
13:1, 2003).
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